Box plots showing the overall benefit-risk scores

These box plots were used in the Natalizumab Wave 1 case study. The overall benefit-risk scores are shown as box plots for direct model (left) and indirect model (right). The quantity on the vertical axis is the overall benefit-risk score, i.e. the overall utility of all 11 outcomes with the appropriate preference weights.The “boxes” indicate the interquartile range of the distribution and the vertical “whiskers” extend to the minimum and maximum simulated values. The median of each distribution is indicated by a black diamond.From a visual inspection of the distribution plots and box-whisker plots, it seems clear that natalizumab is the best treatment option.