RV-MCE (Relative Value adjusted Minimum Clinical Efficacy)

1. Description

RV-MCE (Relative Value adjusted MCE) incorporates stakeholders' value preferences on the importance of AEs into MCE.

2. Evaluation

2.1 Principle

• The principle is based on MCE.

• Relative values (RV) are used to adjust MCE for utilities of benefits and risks.

• RV adjustment threatens the logical soundness of MCE.

• See also RV-NNH.

2.2 Features

• RV-MCE allows several benefits and risks to be included.

• MCE only gives one point estimate (a single value).

• It does not handle uncertainty.

2.3 Visualisation

• There is no specific visualisation for RV-MCE.

2.4 Assessability and accessibility

• MCE is not widely used in statistics or epidemiology, and very rarely used for benefit-risk assessment.

3. References

[1] Holden WL, Juhaeri J, Dai W. Benefit-risk analysis: examples using quantitative methods. Pharmacoepidemiol Drug Saf 2003 Dec;12(8):693-7.
[2] Holden WL, Juhaeri J, Dai W. Benefit-risk analysis: a proposal using quantitative methods. Pharmacoepidemiol Drug Saf 2003 Oct;12(7):611-6.